Region-Specific Network Analysis Reveals That Epigenetic Modifications Outside Transcriptional Start Sites Are Tightly Linked to mRNA

While most data analysis of epigenetic modifications has focused on the transcriptional start site proximal region (TPR), non-TPR received less attention. The understanding interaction relationships and their effects is incomplete, especially for non-TPR. To study among within TPR non-TPR, we presented an original framework, that is, region-specific network, where each gene element was introduced as a new dimension can be separately analyzed based signals. We derived network (EIN) Pearson correlation coefficient partial coefficient. Our CD4+ cells showed majority edges relate to small set nodes in identified EIN. Most strikingly, found introns, exhibit frequent important interactions are closely linked mRNA. Moreover, more consistent behavior different regions genes. Finally, these easily divided into three categories, namely, (i) class interaction, (ii) negative effect (iii) positive effect, last two classes perfectly match previous results. results provide perspective exploring functional mechanisms modification.